Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome
It was found recently that acrolein (CH 2 =CH–CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O 2 −· , H 2 O 2 , and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren’s syndrome is correlated with acr...
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| Veröffentlicht in: | Amino acids 2020-02, Vol.52 (2), p.119-127 |
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| creator | Igarashi, Kazuei Uemura, Takeshi Kashiwagi, Keiko |
| description | It was found recently that acrolein (CH
2
=CH–CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O
2
−·
, H
2
O
2
, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren’s syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity and specificity by measuring protein-conjugated acrolein (PC-Acro) in plasma together with IL-6 and CRP in brain infarction and Aβ
40/42
in dementia. The level of PC-Acro in plasma and saliva correlated with the seriousness of renal failure and Sjӧgren’s syndrome, respectively. Thus, development of acrolein scavenger medicines containing SH-group such as
N
-acetylcysteine derivatives is important to maintain QOL (quality of life) of the elderly. |
| doi_str_mv | 10.1007/s00726-019-02700-x |
| format | Article |
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2
=CH–CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O
2
−·
, H
2
O
2
, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren’s syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity and specificity by measuring protein-conjugated acrolein (PC-Acro) in plasma together with IL-6 and CRP in brain infarction and Aβ
40/42
in dementia. The level of PC-Acro in plasma and saliva correlated with the seriousness of renal failure and Sjӧgren’s syndrome, respectively. Thus, development of acrolein scavenger medicines containing SH-group such as
N
-acetylcysteine derivatives is important to maintain QOL (quality of life) of the elderly.</description><identifier>ISSN: 0939-4451</identifier><identifier>EISSN: 1438-2199</identifier><identifier>DOI: 10.1007/s00726-019-02700-x</identifier><identifier>PMID: 30863888</identifier><language>eng</language><publisher>Vienna: Springer Vienna</publisher><subject>Acetylcysteine ; Acrolein ; Analytical Chemistry ; Biochemical Engineering ; Biochemistry ; Biomedical and Life Sciences ; Brain ; Cerebral infarction ; Dementia ; Dementia disorders ; Failure ; Geriatrics ; Hydrogen peroxide ; Infarction ; Interleukin 6 ; Invited Minireview ; Kidneys ; Life Sciences ; Neurobiology ; Older people ; Polyamines: Biochemical and Pathophysiological Properties ; Proteins ; Proteomics ; Quality of life ; Reactive oxygen species ; Renal failure ; Saliva ; Sjogren's syndrome ; Spermine</subject><ispartof>Amino acids, 2020-02, Vol.52 (2), p.119-127</ispartof><rights>Springer-Verlag GmbH Austria, part of Springer Nature 2019</rights><rights>Amino Acids is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-c716c9a7e44c267ace7957ba4c131c1c81bc0369321aef0130394ca5f61e2ea13</citedby><cites>FETCH-LOGICAL-c441t-c716c9a7e44c267ace7957ba4c131c1c81bc0369321aef0130394ca5f61e2ea13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00726-019-02700-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00726-019-02700-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30863888$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Igarashi, Kazuei</creatorcontrib><creatorcontrib>Uemura, Takeshi</creatorcontrib><creatorcontrib>Kashiwagi, Keiko</creatorcontrib><title>Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome</title><title>Amino acids</title><addtitle>Amino Acids</addtitle><addtitle>Amino Acids</addtitle><description>It was found recently that acrolein (CH
2
=CH–CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O
2
−·
, H
2
O
2
, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren’s syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity and specificity by measuring protein-conjugated acrolein (PC-Acro) in plasma together with IL-6 and CRP in brain infarction and Aβ
40/42
in dementia. The level of PC-Acro in plasma and saliva correlated with the seriousness of renal failure and Sjӧgren’s syndrome, respectively. Thus, development of acrolein scavenger medicines containing SH-group such as
N
-acetylcysteine derivatives is important to maintain QOL (quality of life) of the elderly.</description><subject>Acetylcysteine</subject><subject>Acrolein</subject><subject>Analytical Chemistry</subject><subject>Biochemical Engineering</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Brain</subject><subject>Cerebral infarction</subject><subject>Dementia</subject><subject>Dementia disorders</subject><subject>Failure</subject><subject>Geriatrics</subject><subject>Hydrogen peroxide</subject><subject>Infarction</subject><subject>Interleukin 6</subject><subject>Invited Minireview</subject><subject>Kidneys</subject><subject>Life Sciences</subject><subject>Neurobiology</subject><subject>Older people</subject><subject>Polyamines: Biochemical and Pathophysiological Properties</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Quality of life</subject><subject>Reactive oxygen species</subject><subject>Renal failure</subject><subject>Saliva</subject><subject>Sjogren's syndrome</subject><subject>Spermine</subject><issn>0939-4451</issn><issn>1438-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kUFuFDEQRS0EIkPgAiyQJRZkkQaX7em2l1FESKRILIC15fFUDx667eDqjjIX4wK5GE4mEIkFG5fsevWt-p-x1yDegxDdB6qHbBsBthGyE6K5ecIWoJVpJFj7lC2EVbbRegkH7AXRVgiQBtrn7EAJ0ypjzIJdnxAhUUwb7kPJA8bE-1z4GicsY0x-ijnx3PPpO3LCayxx2t3dV8VXlKaSf-BxxUdMU_THvGDyA-99HOZSGz6t-Zft7a9NfX9HnHZpXfKIL9mz3g-Erx7qIft29vHr6Xlz-fnTxenJZRO0hqkJHbTB-g61DrLtfMDOLruV1wEUBAgGVkGo1ioJHnsBSiirg1_2LaBED-qQHe11r0r-OSNNbowUcBh8wjyTq0ZBdUVLU9G3_6DbPJe6zD0lZGuNlZWSe6qaRVSwd1cljr7sHAh3l4rbp-JqKu4-FXdTh948SM-rEdd_R_7EUAG1B6i20gbL49__kf0N70yZiQ</recordid><startdate>20200201</startdate><enddate>20200201</enddate><creator>Igarashi, Kazuei</creator><creator>Uemura, Takeshi</creator><creator>Kashiwagi, Keiko</creator><general>Springer Vienna</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20200201</creationdate><title>Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome</title><author>Igarashi, Kazuei ; Uemura, Takeshi ; Kashiwagi, Keiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c441t-c716c9a7e44c267ace7957ba4c131c1c81bc0369321aef0130394ca5f61e2ea13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acetylcysteine</topic><topic>Acrolein</topic><topic>Analytical Chemistry</topic><topic>Biochemical Engineering</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Brain</topic><topic>Cerebral infarction</topic><topic>Dementia</topic><topic>Dementia disorders</topic><topic>Failure</topic><topic>Geriatrics</topic><topic>Hydrogen peroxide</topic><topic>Infarction</topic><topic>Interleukin 6</topic><topic>Invited Minireview</topic><topic>Kidneys</topic><topic>Life Sciences</topic><topic>Neurobiology</topic><topic>Older people</topic><topic>Polyamines: Biochemical and Pathophysiological Properties</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Quality of life</topic><topic>Reactive oxygen species</topic><topic>Renal failure</topic><topic>Saliva</topic><topic>Sjogren's syndrome</topic><topic>Spermine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Igarashi, Kazuei</creatorcontrib><creatorcontrib>Uemura, Takeshi</creatorcontrib><creatorcontrib>Kashiwagi, Keiko</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Amino acids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Igarashi, Kazuei</au><au>Uemura, Takeshi</au><au>Kashiwagi, Keiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome</atitle><jtitle>Amino acids</jtitle><stitle>Amino Acids</stitle><addtitle>Amino Acids</addtitle><date>2020-02-01</date><risdate>2020</risdate><volume>52</volume><issue>2</issue><spage>119</spage><epage>127</epage><pages>119-127</pages><issn>0939-4451</issn><eissn>1438-2199</eissn><abstract>It was found recently that acrolein (CH
2
=CH–CHO), mainly produced from spermine, is more toxic than ROS (reactive oxygen species, O
2
−·
, H
2
O
2
, and ·OH). In this review, we describe how the seriousness of brain infarction, dementia, renal failure, and Sjӧgren’s syndrome is correlated with acrolein. In brain infarction and dementia, it was possible to identify incipient patients with high sensitivity and specificity by measuring protein-conjugated acrolein (PC-Acro) in plasma together with IL-6 and CRP in brain infarction and Aβ
40/42
in dementia. The level of PC-Acro in plasma and saliva correlated with the seriousness of renal failure and Sjӧgren’s syndrome, respectively. Thus, development of acrolein scavenger medicines containing SH-group such as
N
-acetylcysteine derivatives is important to maintain QOL (quality of life) of the elderly.</abstract><cop>Vienna</cop><pub>Springer Vienna</pub><pmid>30863888</pmid><doi>10.1007/s00726-019-02700-x</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0939-4451 |
| ispartof | Amino acids, 2020-02, Vol.52 (2), p.119-127 |
| issn | 0939-4451 1438-2199 |
| language | eng |
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| source | SpringerLink Journals - AutoHoldings |
| subjects | Acetylcysteine Acrolein Analytical Chemistry Biochemical Engineering Biochemistry Biomedical and Life Sciences Brain Cerebral infarction Dementia Dementia disorders Failure Geriatrics Hydrogen peroxide Infarction Interleukin 6 Invited Minireview Kidneys Life Sciences Neurobiology Older people Polyamines: Biochemical and Pathophysiological Properties Proteins Proteomics Quality of life Reactive oxygen species Renal failure Saliva Sjogren's syndrome Spermine |
| title | Assessing acrolein for determination of the severity of brain stroke, dementia, renal failure, and Sjögren's syndrome |
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