4CPS-046 Pharmaceutical interventions in antimicrobial treatment in a 150-bed hospital

BackgroundThe correct use of antimicrobial treatment is necessary to ensure their effectiveness, the control of resistance and to avoid the occurrence of adverse reactions.PurposeTo analyse the pharmaceutical interventions (PI) in antimicrobial treatment and quantify the degree of their acceptance.Material and methodsDescriptive and retrospective study in a 150 bed-hospital was made. PI on antimicrobial treatments were analysed over a period of 16 months (December 2016 – March 2018). The collected data were: age, antimicrobial treatment, type of PI and degree of acceptance of the PI. The reasons for PI were classified into: inadequate dosage, dose adjustment due to renal insufficiency, drug change after antibiogram, therapeutic duplicity, suspension of treatment due to inadequate duration and change of route of administration. The degree of acceptance of the PI was detected based on the medical prescription modifications according to the recommendations. The pharmaceutical recommendations were made through the daily evolutions in the patient’s history in the Ticares computer program.ResultsTwo-hundred and forty-four PI were carried out in 132 patients (1.84 PI per patient). The average age of the patients was 79 years (53% women). The PI, according to classification were: 160 (65.6%) PI due to changes in the antimicrobial administration route (92 were accepted, 57.5%); 70 (28.7%) PI due to suspension of treatment due to inadequate duration (44 were accepted, 62.90%); seven (2.9%) PI for dose adjustment due to renal failure (three were accepted, 42.9%); three (1.2%) PI due to therapeutic duplicity (100% accepted); three (1.2%) PI due to inadequate posology (two were accepted, 66.7%); and one (0.4%) PI due to antimicrobial change after antibiogram (the patient was discharged and it could not be confirmed if there was a change in the prescription). Regarding the degree of acceptance, 144 (59%) IP were accepted and 60 (37,29%) IP were not accepted.ConclusionMore than half of the pharmaceutical interventions resulted in a change in the medical prescription according to the recommendation. The pharmaceutical validation adds safety to the hospitalisation process and represents an improvement in the quality of care.References and/or acknowledgementsNo conflict of interest.