4CPS-005 GLP-1 agonist liraglutide as add-on therapy in type 2 diabetes

BackgroundPurposeThe aim of this study was to evaluate the real-world efficacy and safety of adding Liraglutide in inadequately controlled patients with oral antidiabetic drugs.Material and methodsThis observational study assessed the efficacy and safety of GLP-1 agonist Liraglutide used as add-on therapy in a group of 83 type 2 diabetes (T2DM) patients from a community endocrinology practice in a 6 month period (July to September 2017). We have retrospectively analysed epidemiological, anthropometric and laboratory data. The primary endpoint was changes in glycated haemoglobin (HbA1C) and secondary endpoints included changes in body mass index (BMI), blood pressure (BP), biochemical parameters and percentage of patients reporting adverse effects of therapy.Data were analysed using SPSS version 20.0 and comparisons of continuous variables were performed using Student’s t test.ResultsEighty-three patients were included (54.2% male). Mean age 56.76±9.87 years, mean duration of T2DM 9.46±5.46 years. Prior to treatment, patients had BMI 37.68±6.82 Kg/m2, systolic BP (SBP) 138.80±15.46 mmHg, diastolic BP (DBP) 82.87±10.16 mmHg, fasting glucose 187.33±55.11 mg/dL, HbA1C 8.62%±1.3%, total cholesterol 178.1±35.74 mg/dL, LDL cholesterol (c-LDL) 97.66±32.16 mg/dL, HDL cholesterol (c-HDL) 44.54±13.78 mg/dL, triglycerides 197.64±24.19 mg/dL, GOT 29±20.311 U/L and GPT 39.88±31.69 U/L.Clinical and biochemical values at 6 months were: BMI 36.08±6.32 Kg/m2 (p