4CPS-068 Impact of the pharmaceutical recommendations for the improvement in antibiotics prescription

BackgroundAntibiotic prescription has been increased over the past years. A misuse of them has led to an increasing antibiotic-resistant bacteria and side effects in patients. Thus, the goal of pharmaceutical recommendations is to avoid these important issues.PurposeTo analyse the pharmaceutical interventions in antibiotics prescription performed in a third-level hospital and the degree of acceptance per service.Material and methodsA retrospective, observational and descriptive study of the pharmaceutical interventions in antibiotic prescription in our hospital over a 12 month period has been done. Types of interventions were collected from the antibiotic prescription of patients.Pharmaceutical interventions registered were: incorrect dosage (ID), excessive duration (ED), incorrect dosage regime (IDR), pharmaceutical substitution (PS), de-escalation (DE) and other interventions (OI). We also analysed the degree of acceptance of these recommendations per services.Data were collected from an electronic prescription program (Farmatools v. 2.6)ResultsDuring the study period, 312 antibiotic interventions have been registered and analysed.Prescribing services were: internal medicine 56%, emergency department 11%, surgery 9%, urology 5%, oncology and haematology 6%, digestive 4%, pneumology 3%, traumatology 3%, intensive care unit 2% andotorhinolaryngology 1%.Prescribed antibiotic families were: 154 beta-lactam antibiotics (49%), 106 fluoroquinolones (34%), 16 other antibacterials (5%), 14 aminoglycosides (5%), 13 glycopeptides (4%), seven macrolides (2%) and two sulfonamides (1%).Pharmaceutical interventions were: ID 40%, ED 26%, IDR 22%, OI 5%, PS 4% and DE 3%.The degree of acceptance of these recommendations was 42%. We could not evaluate if 58% interventions were accepted. Acceptance per service was: internal medicine 49%, surgery 15%, oncology and haematology 8%, urology 7%, digestive 6%, emergency department 5%, traumatology 5%, intensive care unit 3% and pneumology 2%.ConclusionThe antibiotic family with the highest number of interventions was beta-lactam antibiotics. The most frequent intervention registered was ID. Internal medicine service accepted the highest number of interventions.Data shows that the pharmaceutical role is important in achieving the correct antibiotic prescription. The objective of these recommendations will help to avoid antibiotic-resistance and side effects in patients.References and/or acknowledgementshttps://ejhp.bmj.com/content