4CPS-264 Analysis of the discrepancies found in the reconciliation of concomitant medication in a cohort of elderly patients infected with HIV

BackgroundThe increase of life expectanty in HIV patients leads to the appearance of comorbidities and therefore the increase in concomitant medication.PurposeTo determine the prevalence of discrepancies in the reconciliation of concomitant mediation in elderly HIV patients. To describe the most frequent discrepancies as well as the medications involved.Material and methodsProspective observational study conducted in HIV-infected patients treated at the pharmacy service (1 January 2014–31 December 2014) of a regional university hospital.Collected variables: age, sex, concomitant medications, discrepancies found in the clinical history of specialised care (CH) and primary care (PC) and plasma viral load (VL). The discrepancies were classified as: omission, different dose/frequency/route, erroneous medication and therapeutic duplicity.In the conciliation the CH was reviewed, the pharmacotherapeutic history of PC and the patient was interviewed.The inclusion criteria were: HIV infection, age ≥50 years and antiretroviral treatment for at least 6 months.The statistical analyses were performed using the statistical package SPSS 15.0.ResultsWe analysed 327 patients of which 132 (40,37%) were elderly patients.In the study population (n=132), the median age was 53 years (RI: 50–88), with 61.4% (n=81) being polymedicated patients. 73.5% (n=97) of the population was male.A total of 790 active ingredients were analysed, 439 being concomitant active ingredients. The median of active ingredients/patient was 5 (RI: 1–21). One-hundred and thirty-one active substances with HC discrepancy and 154 active ingredients in PC were registered and 81 patients were affected (61.4%). 81.5% of them (n=66) were polymedicated patients.In CH there were: 109 omissions, 22 erroneous medications and two medications with erroneous doses. In the PC: 132 drug omissions were collected, 21 wrong medications and one medication with the wrong dose. The active ingredients mostly involved belonged to: vitamins (16.17%), psycholeptics (11.0%) and antacids (10.1%).VL was less than 50 copies/ml in 81 patients (61.4%) and less than 200 copies/ml in 119 patients (90.15%).ConclusionSeropositive patients have a high number of discrepances affecting patients’ polymedicated majority. The most frequent discrepancy in both primary and specialised care is the omission of medications. The group of drugs mostly involved are vitamins. It would be interesting to analyse in the future if patients with more discrepa