4CPS-245 Evaluation of the degree of adherence to the intravenous treatment of ambulatory patients

BackgroundThe lack of adherence to the pharmacological treatment of patients with chronic diseases is a prevalent and relevant problem in routine clinical practice.PurposeTo assess the degree of adherence to the non-chemotherapy intravenous treatment of chronic patients who came to the day hospital, as well as to identify the possible specific factors related to therapeutic compliance.Material and methodsA retrospective longitudinal descriptive study of 1 year duration (2017) was carried out. This included patients who went to the day hospital to receive treatment. The adherence data were extracted from the pharmacy service database and day-hospital records. The demographic and clinical data of the patients were obtained from the review of electronic health records: age, gender, pathology and treatment. Besides, the degree of adherence was expressed as a percentage and the results were calculated from the records previously submitted and taking into account the posological interval. Adherence was considered adequate when values equal to or greater than 90% were obtained. On the other hand, the association between the variables studied and the degree of adherence was estimated by means of statistical tests of hypothesis contrast.ResultsA total sample size of 199 patients were included with a mean age of 51 years and 64% of them were females. The most frequent pathology was rheumatoid arthritis (30%), followed by Crohn’s disease (26%) and lupus (10%). In agreement with this fact, the most frequently infused drug was infliximab (38.7%), followed by tocilizumab (24%) and belimumab (10%). Adherence to the treatment was considered inadequate in 22% of patients. Females had a higher degree of non-adherence (61%) than males. The variables that showed a statistically significant association with adherence to the treatment were the drug delivered, the dosage interval and the duration of the infusion (Chi square-test with p