Thiocyanation of Enamines of the 3,3-Dialkyl-1,2,3,4-tetrahydroisoquinoline Series

Thiocyanation of Enamines of the 3,3-Dialkyl-1,2,3,4-tetrahydroisoquinoline Series

Thiocyanation of secondary enamines of the 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series and their benzo[ f ]-fused analogs (esters, amides, ketones, and nitriles) with thiocyanogen generated in situ afforded thiazolo[4,3- a ]isoquinoline derivatives. Analogous reaction with a tertiary enamino k...

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Veröffentlicht in:Russian journal of organic chemistry 2018-12, Vol.54 (12), p.1815-1818
Hauptverfasser: Mikhailovskii, A. G., Peretyagin, D. A.
Format: Artikel
Sprache:eng
Schlagworte:
Amides
Chemistry
Chemistry and Materials Science
Esters
Ketones
Nitriles
Organic Chemistry
Substitution reactions
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Zusammenfassung:Thiocyanation of secondary enamines of the 3,3-dialkyl-1,2,3,4-tetrahydroisoquinoline series and their benzo[ f ]-fused analogs (esters, amides, ketones, and nitriles) with thiocyanogen generated in situ afforded thiazolo[4,3- a ]isoquinoline derivatives. Analogous reaction with a tertiary enamino ketone gave product of hydrogen substitution at the β-carbon atom of the enamine fragment.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428018120138