Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach

Direct Metal‐Free Preparation of Functionalizable Polylactic Acid‐Ethisterone Conjugates in a One‐Pot Approach

A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionaliza...

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Veröffentlicht in:Macromolecular chemistry and physics 2019-03, Vol.220 (5), p.n/a
Hauptverfasser: Luo, Shi‐He, Wu, Yan‐Cheng, Cao, Liang, Lin, Jian‐Yun, Gao, Jian, Chen, Shui‐Xia, Wang, Zhao‐Yang
Format: Artikel
Sprache:eng
Schlagworte:
Biodegradable materials
biomaterials
Biopolymers
Chemical synthesis
Conjugates
copolymerization
Direct melting
Drug delivery systems
functionalization of polymers
Organic chemistry
polycondensation
Polylactic acid
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Zusammenfassung:A series of polylactic acid (PLA) conjugates (PLA‐ES) are synthesized via direct melt polycondensation (DMP) of lactic acid (LA) with ethisterone (ES) in the presence of 0.3 wt% toluenesulfonic acid at 160 °C for 6 h. The drug content of PLA conjugates can be simply adjustable. Further functionalization via Click chemistry is also achieved to extend the biomedicine application of biopolymer based drug delivery. A method for merging polymeric carrier preparation and chemical conjugation into one‐pot, via solvent‐ and metal‐free direct melt polycondensation, for functionalizable polylactic acid‐ethisterone (PLA‐ES) conjugates is developed.
ISSN:1022-1352
1521-3935
DOI:10.1002/macp.201800475