Electrochemical Synthesis of 2-(2-Chlorophenyl)-2-[(3,4- dihydroxyphenyl)(methyl)amino]cyclohexanone

Electrochemical oxidation of catechol has been studied in the presence of ketamine as a drug in phosphate buffer solution mixed with ethanol using voltammetric techniques. The obtained results indicated that the o -quinone formed from electro-oxidation of catechol participated in a 1,4-Michael addit...

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Veröffentlicht in:Russian journal of electrochemistry 2018-12, Vol.54 (12), p.1278-1283
Hauptverfasser: Najafi, M., Lajvardi, M. M., Youseftabar-Miri, L., Ameri, M., Ghaderi, O.
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Sprache:eng
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Zusammenfassung:Electrochemical oxidation of catechol has been studied in the presence of ketamine as a drug in phosphate buffer solution mixed with ethanol using voltammetric techniques. The obtained results indicated that the o -quinone formed from electro-oxidation of catechol participated in a 1,4-Michael addition reaction to form the corresponding new 2-(2-chlorophenyl)-2-[(3,4-dihydroxyphenyl)(methyl)amino]cyclohexanone under ECE mechanism. The electro-organic synthesis has been successfully performed under mild condition in a divided cell in good yield.
ISSN:1023-1935
1608-3342
DOI:10.1134/S1023193518130311