Adenoviral overexpression of interleukin-1 receptor antagonist protein increases [beta]-cell replication in rat pancreatic islets

Adenoviral overexpression of interleukin-1 receptor antagonist protein increases [beta]-cell replication in rat pancreatic islets

The naturally occurring inhibitor of interleukin-1 (IL-1) action, interleukin-1 receptor antagonist protein (IRAP), binds to the type 1 IL-1 receptor but does not initiate IL-1 signal transduction. In this study, we have determined the effects of IL-1beta and IRAP overexpression on adult beta-cell r...

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Veröffentlicht in:Gene therapy 2005-01, Vol.12 (2), p.120
Hauptverfasser: Téllez, N, Montolio, M, Biarnés, M, Castaño, E, Soler, J, Montanya, E
Format: Artikel
Sprache:eng
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Zusammenfassung:The naturally occurring inhibitor of interleukin-1 (IL-1) action, interleukin-1 receptor antagonist protein (IRAP), binds to the type 1 IL-1 receptor but does not initiate IL-1 signal transduction. In this study, we have determined the effects of IL-1beta and IRAP overexpression on adult beta-cell replication and viability. IL-1beta reduced dramatically beta-cell replication in adult rat islets both at 5.5 mM (control: 0.29+/-0.04%; IL-1beta: 0.02+/-0.02%, P
ISSN:0969-7128
1476-5462
DOI:10.1038/sj.gt.3302351