Synthesis of novel pentacyclic -lactam antibacterial agents

Synthesis of novel pentacyclic -lactam antibacterial agents

The search for new antibacterial agents still represents an active area of research. In this paper the synthesis of a new class of -lactam agents characterized by an interesting antibacterial profile is reported; together with a description of the most significant synthetic aspects encountered durin...

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Veröffentlicht in:Canadian journal of chemistry 2000-06, Vol.78 (6), p.772-775
Hauptverfasser: Andreotti, Daniele, Biondi, Stefano, Donati, Daniele, Lociuro, Sergio, Pain, Gilles
Format: Artikel
Sprache:eng
Schlagworte:
Antibacterial agents
Bacteria
Chemical reactions
Chemistry
Disinfection & disinfectants
Lactams
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Zusammenfassung:The search for new antibacterial agents still represents an active area of research. In this paper the synthesis of a new class of -lactam agents characterized by an interesting antibacterial profile is reported; together with a description of the most significant synthetic aspects encountered during this work.Key words: -lactams, pentacyclic, O-alkylation, trinem.
ISSN:0008-4042
1480-3291
DOI:10.1139/v00-056