Construction of bicyclic tetrahydroisoquinolinones by combination of an IMDAF-ring cleavage reaction of N-allyl-2-furan-yl-acetamides

The intrameolecular Diels-Alder reaction of furanyl amides derived from 2-furylacetic acid has been examined. Substrates containing either an imide or tertiary amide linkage betwen the furan and the dienophile undersent smooth cycloaddition upon thermolysis.

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Veröffentlicht in:Canadian journal of chemistry 2000-06, Vol.78 (6), p.749
Hauptverfasser: Padwa, Albert, Reger, Thomas S
Format: Artikel
Sprache:eng
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Zusammenfassung:The intrameolecular Diels-Alder reaction of furanyl amides derived from 2-furylacetic acid has been examined. Substrates containing either an imide or tertiary amide linkage betwen the furan and the dienophile undersent smooth cycloaddition upon thermolysis.
ISSN:0008-4042
1480-3291