R-1-Phenylethylamine as chiral auxiliary in the diastereoselective synthesis of tetrahydro-3- carboline derivatives

R-1-Phenylethylamine as chiral auxiliary in the diastereoselective synthesis of tetrahydro-3- carboline derivatives

Modified sodium borohydrides were used in the reduction of the imine moiety in compounds containing the (R)-1-arylethylamine motif as a chiral auxiliary. Diastereomeric products were formed with moderate to good stereoselectivity and were effectively separated by column chromatography. [PUBLICATION...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Canadian journal of chemistry 2007-12, Vol.85 (12), p.1033
Hauptverfasser: Siwicka, Aleksandra, Wojtasiewicz, Krystyna, Leniewski, Andrzej, Maurin, Jan K, Zawadzka, Anna, Czarnocki, Zbigniew
Format: Artikel
Sprache:eng
Schlagworte:
Chemical compounds
Chemical synthesis
Chromatography
Hydrogen bonds
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Modified sodium borohydrides were used in the reduction of the imine moiety in compounds containing the (R)-1-arylethylamine motif as a chiral auxiliary. Diastereomeric products were formed with moderate to good stereoselectivity and were effectively separated by column chromatography. [PUBLICATION ABSTRACT]
ISSN:0008-4042
1480-3291