Determination of vancomycin pharmacokinetics in critically ill intensive care unit patients in Malaysia: A population pharmacokinetic analysis with a nonparametric approach

Despite the vital role of vancomycin in the treatment of MRSA infections, a complete consensus has not been reached regarding the optimum dosing regimens and PK/PD goals in critically ill patients. Since there are limited studies worldwide, this study is, therefore, intended to explore the vancomyci...

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Veröffentlicht in:National journal of physiology, pharmacy and pharmacology pharmacy and pharmacology, 2018, Vol.8 (9), p.1-1679
Hauptverfasser: Mustafa, Suzana, Ali, Mohd, Mohamed, Azhar, Azmi, Nazmi, Bahar, Nurul, Sukri, Rosaidaremanja, Azhari, Afifah
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Sprache:eng
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Zusammenfassung:Despite the vital role of vancomycin in the treatment of MRSA infections, a complete consensus has not been reached regarding the optimum dosing regimens and PK/PD goals in critically ill patients. Since there are limited studies worldwide, this study is, therefore, intended to explore the vancomycin population PK parameters in critically ill ICU patients in Hospital Raja Perempuan Zainab (HRPZ) II, Kelantan, Malaysia. [...]covariate analysis processes help to detect the relationship between PK parameters and covariates of interest. [...]the parametric approach is unable to do this because it does not use the entire model parameter distributions. [...]it cannot evaluate and maximize the expected precision with which the dosage regimen hits a clinically selected target goal. [...]Pmetrics calculates the likelihood function exactly and thus possesses statistical consistency in contrast to parametric approaches.
ISSN:2320-4672
2231-3206
DOI:10.5455/njppp.2018.8.1030815102018