Neurotrophic effects of turmeric on the memory of the mouse using the Morris water maze test

[...]the pre-treatment and post-treatment difference (not shown in graph) among the groups were 1.15 (control), 2 (5 mg/kg), 5.05 (15 mg/kg), and 7.2 (45 mg/kg). [...]the graph reveals a downhill trend on the post-treatment administration, which may suggest that with higher doses, the mice were able to locate the platform at a lesser time [Figure 2]. [17] In another study by Noorafshan et al.,[18] curcumin prevented sulfite-induced learning and memory changes in rats. [...]curcumin treatment significantly improved colchicine-induced cognitive impairment in mice by decreasing lipid peroxidation. Turmeric extract has been proven by the US FDA to be safe in animal studies and declared curcumin as generally regarded as safe. [...]turmeric may have a protective effect on the memory by preventing programmed cell death or apoptosis and in turn, may be a potential neuroprotective agent in the prevention of oxidative stress. Curcumin as an antioxidant was thought to efficiently donate hydrogen atoms contain different functional groups necessary for scavenging free radicals and degrade into even smaller yet powerful antioxidants. [...]more studies must be conducted to determine its biochemical pathway, synthesis, as well as its adverse effects on the memory.