Green synthesis of 1,2,3‐triazoles via Cu2O NPs on hydrogen trititanate nanotubes promoted 1,3‐dipolar cycloadditions

Cu2O nanoparticles supported on hydrogen trititanate nanotubes (Cu2O/HTNT) catalysts have been efficiently catalyzed the multicomponent synthesis of 1,2,3‐triazoles in water at room temperature from different azide precursors, for example organic halides, sulfonates and anilines. The catalysts were synthesized by hydrothermal & wet‐impregnation methods and was characterized by HR‐TEM, EDS, XRD, XPS, N2‐adsorption desorption and ICP‐MS analysis. The catalyst could be recycled by centrifugation and reused up to seven cycles. The 1‐benzyl‐4‐(4‐chlorophenyl)‐1H‐1,2,3‐triazole (25) structure was proven by single crystal X‐ray diffraction studies. An efficient Cu2O nanoparticles/hydrogen trititanate nanotubes catalyzed 1,2,3‐triazoles has been achieved through one pot azidation/1,3 dipolar cycloaddition of in situ generated azides and alkynes in water.