Palladium acetate-catalysed one-pot green synthesis of bis α-aminophosphonates

A simple and effective green method has been developed for the synthesis of a series of novel bis α -aminophosphonate derivatives ( 4a–j) by the reaction of 1,4-diaminonaphthalene, various aryl/heteroaryl aldehydes and dialkyl phosphites under neat and microwave irradiation conditions using palladium acetate as catalyst. The products are characterized by elemental analysis, IR, 1 H, 13 C, 31 P-NMR and mass spectra and their antioxidant activities are evaluated by DPPH, NO and H 2 O 2 methods and molecular docking studies. The compounds 4d and 4h exhibited the highest radical scavenging activity in the DPPH method, while compounds 4a , 4e and 4f showed good NO scavenging activity. The compound 4g showed remarkably higher H 2 O 2 scavenging activity than even the standard ascorbic acid, and compound 4h has stronger inhibiting activity on DNA gyrase enzyme.