Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy
Purpose Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of...
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| Veröffentlicht in: | Supportive care in cancer 2019-10, Vol.27 (10), p.3849-3857 |
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| creator | McCrary, J. Matt Goldstein, David Sandler, Carolina X. Barry, Benjamin K. Marthick, Michael Timmins, Hannah C. Li, Tiffany Horvath, Lisa Grimison, Peter Park, Susanna B. |
| description | Purpose
Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of a multimodal exercise intervention on CIPN symptoms and related functional deficits, as well as neurophysiologic parameters.
Methods
All outcomes were assessed before and after an 8-week exercise intervention (3-weekly sessions) and preceding 8-week control period at baseline, pre-exercise and post-exercise. Outcome measures were objective and patient-reported CIPN, standing and dynamic balance, mobility, quality of life, and sensory and motor nerve excitability and conduction studies.
Results
Twenty-nine cancer survivors (8 male, 21 female; mean age 61.6 ± 11.8 years) with CIPN symptoms affecting function completed all assessments. Objective and patient-reported CIPN, dynamic balance, standing balance in eyes open conditions, mobility and quality of life were improved from pre- to post-exercise (4.0 |
| doi_str_mv | 10.1007/s00520-019-04680-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2178841308</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A598461734</galeid><sourcerecordid>A598461734</sourcerecordid><originalsourceid>FETCH-LOGICAL-c442t-89ae75267d40c5ed29bc0366d5fe1daf7ae7ce445ac5a85753995ef10ee94af83</originalsourceid><addsrcrecordid>eNp9kU1r3DAQhkVpaTYff6CHYuhZ6ciSLOsYQtoGAr2kZyHLo1hhbbmSne3--yjd9AtK0EEw8zyjES8h7xicMwD1MQPIGigwTUE0LdDdK7JhgnOqONevyQa0YFRwKY_Icc73AEwpWb8lRxyUbOpab0h39QOTCxlpZzP2VcLBdmEbFruEOFU-psrZyWGq8poewkNMudqFZajcgGNcBkx23tMw9asr9owpzE-1bTXhmuJsl2F_St54u8149nyfkG-frm4vv9Cbr5-vLy9uqBOiXmirLZbtGtULcBL7WncOeNP00iPrrVel7VAIaZ20rVSSay3RM0DUwvqWn5APh7lzit9XzIu5j2uaypOmZqptBePwF3Vnt2jC5OOSrBtDduZC6lY0THFRqPP_UOX0OAYXJ_Sh1P8R6oPgUsw5oTdzCqNNe8PAPKVlDmmZkpb5mZbZFen988ZrN2L_W_kVTwH4AcilNd1h-vOlF8Y-AvN7oWc</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2178841308</pqid></control><display><type>article</type><title>Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>McCrary, J. Matt ; Goldstein, David ; Sandler, Carolina X. ; Barry, Benjamin K. ; Marthick, Michael ; Timmins, Hannah C. ; Li, Tiffany ; Horvath, Lisa ; Grimison, Peter ; Park, Susanna B.</creator><creatorcontrib>McCrary, J. Matt ; Goldstein, David ; Sandler, Carolina X. ; Barry, Benjamin K. ; Marthick, Michael ; Timmins, Hannah C. ; Li, Tiffany ; Horvath, Lisa ; Grimison, Peter ; Park, Susanna B.</creatorcontrib><description>Purpose
Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of a multimodal exercise intervention on CIPN symptoms and related functional deficits, as well as neurophysiologic parameters.
Methods
All outcomes were assessed before and after an 8-week exercise intervention (3-weekly sessions) and preceding 8-week control period at baseline, pre-exercise and post-exercise. Outcome measures were objective and patient-reported CIPN, standing and dynamic balance, mobility, quality of life, and sensory and motor nerve excitability and conduction studies.
Results
Twenty-nine cancer survivors (8 male, 21 female; mean age 61.6 ± 11.8 years) with CIPN symptoms affecting function completed all assessments. Objective and patient-reported CIPN, dynamic balance, standing balance in eyes open conditions, mobility and quality of life were improved from pre- to post-exercise (4.0 <
F
< 10.2;
p
< .05), with no changes over the control period (
p
> .21). No changes were observed in sensory or motor neurophysiologic parameters (
p
> .23).
Conclusions
This study provides encouraging evidence of the rehabilitative potential of multimodal exercise for persisting CIPN in a post-treatment cohort. Large randomised controlled trials are justified to confirm observed benefits and determine the mechanisms and clinical significance.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-019-04680-w</identifier><identifier>PMID: 30756229</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Antineoplastic Agents - adverse effects ; Antineoplastic Agents - therapeutic use ; Cancer ; Cancer Survivors ; Care and treatment ; Chemotherapy ; Clinical significance ; Cohort Studies ; Exercise ; Exercise - physiology ; Exercise therapy ; Exercise Therapy - methods ; Female ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasms - drug therapy ; Neurophysiology ; Nursing ; Nursing Research ; Oncology ; Original Article ; Outcome Assessment, Health Care ; Oxaliplatin - adverse effects ; Oxaliplatin - therapeutic use ; Paclitaxel - adverse effects ; Paclitaxel - therapeutic use ; Pain Medicine ; Patient compliance ; Peripheral Nervous System Diseases - chemically induced ; Peripheral Nervous System Diseases - therapy ; Peripheral neuropathy ; Quality of Life ; Rehabilitation Medicine ; Strength training ; Survivor ; Vincristine</subject><ispartof>Supportive care in cancer, 2019-10, Vol.27 (10), p.3849-3857</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Supportive Care in Cancer is a copyright of Springer, (2019). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c442t-89ae75267d40c5ed29bc0366d5fe1daf7ae7ce445ac5a85753995ef10ee94af83</citedby><cites>FETCH-LOGICAL-c442t-89ae75267d40c5ed29bc0366d5fe1daf7ae7ce445ac5a85753995ef10ee94af83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-019-04680-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-019-04680-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30756229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McCrary, J. Matt</creatorcontrib><creatorcontrib>Goldstein, David</creatorcontrib><creatorcontrib>Sandler, Carolina X.</creatorcontrib><creatorcontrib>Barry, Benjamin K.</creatorcontrib><creatorcontrib>Marthick, Michael</creatorcontrib><creatorcontrib>Timmins, Hannah C.</creatorcontrib><creatorcontrib>Li, Tiffany</creatorcontrib><creatorcontrib>Horvath, Lisa</creatorcontrib><creatorcontrib>Grimison, Peter</creatorcontrib><creatorcontrib>Park, Susanna B.</creatorcontrib><title>Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of a multimodal exercise intervention on CIPN symptoms and related functional deficits, as well as neurophysiologic parameters.
Methods
All outcomes were assessed before and after an 8-week exercise intervention (3-weekly sessions) and preceding 8-week control period at baseline, pre-exercise and post-exercise. Outcome measures were objective and patient-reported CIPN, standing and dynamic balance, mobility, quality of life, and sensory and motor nerve excitability and conduction studies.
Results
Twenty-nine cancer survivors (8 male, 21 female; mean age 61.6 ± 11.8 years) with CIPN symptoms affecting function completed all assessments. Objective and patient-reported CIPN, dynamic balance, standing balance in eyes open conditions, mobility and quality of life were improved from pre- to post-exercise (4.0 <
F
< 10.2;
p
< .05), with no changes over the control period (
p
> .21). No changes were observed in sensory or motor neurophysiologic parameters (
p
> .23).
Conclusions
This study provides encouraging evidence of the rehabilitative potential of multimodal exercise for persisting CIPN in a post-treatment cohort. Large randomised controlled trials are justified to confirm observed benefits and determine the mechanisms and clinical significance.</description><subject>Adult</subject><subject>Aged</subject><subject>Antineoplastic Agents - adverse effects</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Cancer</subject><subject>Cancer Survivors</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical significance</subject><subject>Cohort Studies</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Exercise therapy</subject><subject>Exercise Therapy - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasms - drug therapy</subject><subject>Neurophysiology</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Outcome Assessment, Health Care</subject><subject>Oxaliplatin - adverse effects</subject><subject>Oxaliplatin - therapeutic use</subject><subject>Paclitaxel - adverse effects</subject><subject>Paclitaxel - therapeutic use</subject><subject>Pain Medicine</subject><subject>Patient compliance</subject><subject>Peripheral Nervous System Diseases - chemically induced</subject><subject>Peripheral Nervous System Diseases - therapy</subject><subject>Peripheral neuropathy</subject><subject>Quality of Life</subject><subject>Rehabilitation Medicine</subject><subject>Strength training</subject><subject>Survivor</subject><subject>Vincristine</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1r3DAQhkVpaTYff6CHYuhZ6ciSLOsYQtoGAr2kZyHLo1hhbbmSne3--yjd9AtK0EEw8zyjES8h7xicMwD1MQPIGigwTUE0LdDdK7JhgnOqONevyQa0YFRwKY_Icc73AEwpWb8lRxyUbOpab0h39QOTCxlpZzP2VcLBdmEbFruEOFU-psrZyWGq8poewkNMudqFZajcgGNcBkx23tMw9asr9owpzE-1bTXhmuJsl2F_St54u8149nyfkG-frm4vv9Cbr5-vLy9uqBOiXmirLZbtGtULcBL7WncOeNP00iPrrVel7VAIaZ20rVSSay3RM0DUwvqWn5APh7lzit9XzIu5j2uaypOmZqptBePwF3Vnt2jC5OOSrBtDduZC6lY0THFRqPP_UOX0OAYXJ_Sh1P8R6oPgUsw5oTdzCqNNe8PAPKVlDmmZkpb5mZbZFen988ZrN2L_W_kVTwH4AcilNd1h-vOlF8Y-AvN7oWc</recordid><startdate>20191001</startdate><enddate>20191001</enddate><creator>McCrary, J. Matt</creator><creator>Goldstein, David</creator><creator>Sandler, Carolina X.</creator><creator>Barry, Benjamin K.</creator><creator>Marthick, Michael</creator><creator>Timmins, Hannah C.</creator><creator>Li, Tiffany</creator><creator>Horvath, Lisa</creator><creator>Grimison, Peter</creator><creator>Park, Susanna B.</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20191001</creationdate><title>Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy</title><author>McCrary, J. Matt ; Goldstein, David ; Sandler, Carolina X. ; Barry, Benjamin K. ; Marthick, Michael ; Timmins, Hannah C. ; Li, Tiffany ; Horvath, Lisa ; Grimison, Peter ; Park, Susanna B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c442t-89ae75267d40c5ed29bc0366d5fe1daf7ae7ce445ac5a85753995ef10ee94af83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antineoplastic Agents - adverse effects</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Cancer</topic><topic>Cancer Survivors</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical significance</topic><topic>Cohort Studies</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Exercise therapy</topic><topic>Exercise Therapy - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasms - drug therapy</topic><topic>Neurophysiology</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Outcome Assessment, Health Care</topic><topic>Oxaliplatin - adverse effects</topic><topic>Oxaliplatin - therapeutic use</topic><topic>Paclitaxel - adverse effects</topic><topic>Paclitaxel - therapeutic use</topic><topic>Pain Medicine</topic><topic>Patient compliance</topic><topic>Peripheral Nervous System Diseases - chemically induced</topic><topic>Peripheral Nervous System Diseases - therapy</topic><topic>Peripheral neuropathy</topic><topic>Quality of Life</topic><topic>Rehabilitation Medicine</topic><topic>Strength training</topic><topic>Survivor</topic><topic>Vincristine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCrary, J. Matt</creatorcontrib><creatorcontrib>Goldstein, David</creatorcontrib><creatorcontrib>Sandler, Carolina X.</creatorcontrib><creatorcontrib>Barry, Benjamin K.</creatorcontrib><creatorcontrib>Marthick, Michael</creatorcontrib><creatorcontrib>Timmins, Hannah C.</creatorcontrib><creatorcontrib>Li, Tiffany</creatorcontrib><creatorcontrib>Horvath, Lisa</creatorcontrib><creatorcontrib>Grimison, Peter</creatorcontrib><creatorcontrib>Park, Susanna B.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCrary, J. Matt</au><au>Goldstein, David</au><au>Sandler, Carolina X.</au><au>Barry, Benjamin K.</au><au>Marthick, Michael</au><au>Timmins, Hannah C.</au><au>Li, Tiffany</au><au>Horvath, Lisa</au><au>Grimison, Peter</au><au>Park, Susanna B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2019-10-01</date><risdate>2019</risdate><volume>27</volume><issue>10</issue><spage>3849</spage><epage>3857</epage><pages>3849-3857</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Chemotherapy-induced peripheral neuropathy (CIPN) affects up to 40% of cancer survivors and is associated with functional deficits and an increased falls incidence. There are presently no strongly recommended treatment strategies for CIPN. The aim of this study was to evaluate the impact of a multimodal exercise intervention on CIPN symptoms and related functional deficits, as well as neurophysiologic parameters.
Methods
All outcomes were assessed before and after an 8-week exercise intervention (3-weekly sessions) and preceding 8-week control period at baseline, pre-exercise and post-exercise. Outcome measures were objective and patient-reported CIPN, standing and dynamic balance, mobility, quality of life, and sensory and motor nerve excitability and conduction studies.
Results
Twenty-nine cancer survivors (8 male, 21 female; mean age 61.6 ± 11.8 years) with CIPN symptoms affecting function completed all assessments. Objective and patient-reported CIPN, dynamic balance, standing balance in eyes open conditions, mobility and quality of life were improved from pre- to post-exercise (4.0 <
F
< 10.2;
p
< .05), with no changes over the control period (
p
> .21). No changes were observed in sensory or motor neurophysiologic parameters (
p
> .23).
Conclusions
This study provides encouraging evidence of the rehabilitative potential of multimodal exercise for persisting CIPN in a post-treatment cohort. Large randomised controlled trials are justified to confirm observed benefits and determine the mechanisms and clinical significance.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>30756229</pmid><doi>10.1007/s00520-019-04680-w</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0941-4355 |
| ispartof | Supportive care in cancer, 2019-10, Vol.27 (10), p.3849-3857 |
| issn | 0941-4355 1433-7339 |
| language | eng |
| recordid | cdi_proquest_journals_2178841308 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Cancer Cancer Survivors Care and treatment Chemotherapy Clinical significance Cohort Studies Exercise Exercise - physiology Exercise therapy Exercise Therapy - methods Female Humans Male Medicine Medicine & Public Health Middle Aged Neoplasms - drug therapy Neurophysiology Nursing Nursing Research Oncology Original Article Outcome Assessment, Health Care Oxaliplatin - adverse effects Oxaliplatin - therapeutic use Paclitaxel - adverse effects Paclitaxel - therapeutic use Pain Medicine Patient compliance Peripheral Nervous System Diseases - chemically induced Peripheral Nervous System Diseases - therapy Peripheral neuropathy Quality of Life Rehabilitation Medicine Strength training Survivor Vincristine |
| title | Exercise-based rehabilitation for cancer survivors with chemotherapy-induced peripheral neuropathy |
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