Screening for high-affinity ligands to the Src SH2 domain using capillary isoelectric focusing-electrospray ionization trap mass spectometry

Screening for high-affinity ligands to the Src SH2 domain using capillary isoelectric focusing-electrospray ionization trap mass spectometry

A solution-based microscale approach for determination of high-affinity noncovalent complexes from mixtures of compounds is presented, based on capillary isoelectric focusing coupled on-line with electrospray ionization ion trap mass spectrometry.

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Veröffentlicht in:Analytical chemistry (Washington) 1998-11, Vol.70 (22), p.4761
Hauptverfasser: Lyubarskaya, Yelena V, Carr, Steven A, Dunnington, Damien, Prichett, William P
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Scientific imaging
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Zusammenfassung:A solution-based microscale approach for determination of high-affinity noncovalent complexes from mixtures of compounds is presented, based on capillary isoelectric focusing coupled on-line with electrospray ionization ion trap mass spectrometry.
ISSN:0003-2700
1520-6882