Quantitative analysis of etheno-2'-deoxycytidine DNA adducts using on-line immunotaffinity chromatography coupled with LC/ES-MS/MS detection

Quantitative analysis of etheno-2'-deoxycytidine DNA adducts using on-line immunotaffinity chromatography coupled with LC/ES-MS/MS detection

Etheno DNA adducts, including 3,N4-etbeno-2'-deoxycytidine (etheno-dC), are promutagenic lesions present in normal animal and human tissues. These DNA adducts are believed to be important in the etiology of cancer.

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Veröffentlicht in:Analytical chemistry (Washington) 2001-01, Vol.73 (2), p.303
Hauptverfasser: Roberts, Dean W, Churchwell, Mona I, Beland, Frederick A, Jia-Long, Feng, Doerge, Daniel R
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Chromatography
Deoxyribonucleic acid
DNA
Scientific imaging
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Zusammenfassung:Etheno DNA adducts, including 3,N4-etbeno-2'-deoxycytidine (etheno-dC), are promutagenic lesions present in normal animal and human tissues. These DNA adducts are believed to be important in the etiology of cancer.
ISSN:0003-2700
1520-6882