Kinetic Analysis and Subambient Temperature Chromatography of an Active Ester

A normal phase high-performance liquid chromatography gradient is developed using nonprotic solvents and a diol stationary phase to determine the impurity profile of a mesylate that undergoes intramolecular ring closure to a cyclic ether.

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Bibliographische Detailangaben
Veröffentlicht in:	Analytical chemistry (Washington) 1995-07, Vol.67 (13), p.2292-2295
Hauptverfasser:	Egekeze, John O, Danielski, Michael C, Grinberg, Nelu, Smith, George B, Sidler, Daniel R, Perpall, Holly J, Bicker, Gary R, Tway, Patricia C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Exact sciences and technology Kinetics Other chromatographic methods Solvents
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Beschreibung
Zusammenfassung:	A normal phase high-performance liquid chromatography gradient is developed using nonprotic solvents and a diol stationary phase to determine the impurity profile of a mesylate that undergoes intramolecular ring closure to a cyclic ether.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac00109a059