Effect of the chain mobility of polymeric reversed-phase stationary phases on polypeptide retention

Polypeptide resolution in reversed-phase chromatography can be improved by inducing conformational changes in the solute. Protein unfolding can be achieved by an increased accessability of the hydrophobic stationary phase.

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Bibliographische Detailangaben
Veröffentlicht in:	Analytical chemistry (Washington) 1993-09, Vol.65 (17), p.2249-2253
Hauptverfasser:	Hanson, Michael, Unger, Klaus K, Schmid, Jutta, Albert, Klaus, Bayer, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Applied sciences Chemistry Exact sciences and technology Organic polymers Physicochemistry of polymers Polymers Properties and characterization Special properties (catalyst, reagent or carrier)
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Polypeptide resolution in reversed-phase chromatography can be improved by inducing conformational changes in the solute. Protein unfolding can be achieved by an increased accessability of the hydrophobic stationary phase.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac00065a014