Improvement of signal reproducibility and matrix/comatrix effects in MALDI analysis

Improvement of signal reproducibility and matrix/comatrix effects in MALDI analysis

A study examined the main problems associated with matrix-assisted laser desorption/ionization quantitative analysis: poor shot-to-shot reproducibility, crystal inhomogeneity, signal degradation and data acquisition system nonlinearity.

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Bibliographische Detailangaben
Veröffentlicht in:Analytical chemistry (Washington) 1995-03, Vol.67 (6), p.1034-1041
Hauptverfasser: Gusev, Arkady I., Wilkinson, William R., Proctor, Andrew, Hercules, David M.
Format: Artikel
Sprache:eng
Schlagworte:
Chemistry
Ions
Lasers
Scientific imaging
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Beschreibung
Zusammenfassung:A study examined the main problems associated with matrix-assisted laser desorption/ionization quantitative analysis: poor shot-to-shot reproducibility, crystal inhomogeneity, signal degradation and data acquisition system nonlinearity.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00102a003