Polymorphisms of the vitamin D receptor gene (FOKI, CDX2, and GATA) and susceptibility to chronic periodontitis in diabetic and non‐diabetic individuals: A case‐control study

Aim The aim of the present study was to evaluate the distribution of single‐nucleotide polymorphisms (SNP) (variants FOKI [rs2228570], CDX2 [rs47908762], and GATA [rs4516035]) in the vitamin D receptor in individuals with type 2 diabetes mellitus and chronic periodontitis (DM2 + CP), CP alone, and h...

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Veröffentlicht in:	Journal of investigative and clinical dentistry 2019-02, Vol.10 (1), p.e12370-n/a
Hauptverfasser:	Pinho, Roberto C. M., Dias, Rayanne S. A. de M., Bandeira, Francisco, Farias Rodrigues, Jessyca K., Silva, Ronaldo C., Crovella, Sergio, Santos, Erinaldo U. D., Cimões, Renata
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles Brazil Case-Control Studies CDX2 CDX2 protein CDX2 Transcription Factor - genetics chronic periodontitis Chronic Periodontitis - complications Chronic Periodontitis - epidemiology Chronic Periodontitis - genetics Dental Plaque Index Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Female FokI GATA Genetic Predisposition to Disease Genotype Genotyping Techniques Gingival bleeding index Gum disease Humans Male Middle Aged Odds Ratio Periodontitis Plaque index Polymerase chain reaction Polymorphism, Single Nucleotide Receptors, Calcitriol - genetics Single-nucleotide polymorphism Smoking Teeth Vitamin D vitamin D receptor Young Adult
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Zusammenfassung:	Aim The aim of the present study was to evaluate the distribution of single‐nucleotide polymorphisms (SNP) (variants FOKI [rs2228570], CDX2 [rs47908762], and GATA [rs4516035]) in the vitamin D receptor in individuals with type 2 diabetes mellitus and chronic periodontitis (DM2 + CP), CP alone, and healthy individuals, and to investigate the relationship with susceptibility to CP. Methods In total, 280 individuals (116 with DM2 + CP, 95 with CP alone, and 69 healthy individuals) were genotyped using real‐time polymerase chain reaction with allele‐specific probes. Significant differences (P
ISSN:	2041-1618 2041-1626
DOI:	10.1111/jicd.12370