Thermodynamic study of the marked differences between acetonitrile/water and methanol/water mobile-phase systems in reversed-phase liquid chromatography

A thermodynamic approach that considers partitioning of solute molecules between the mobile phase and stationary phase and relates the enthalpy and entropy of solute transfer to the solute partial molar excess quantities is described for the evaluation of the relative contributions of the two phases...

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Veröffentlicht in:Analytical chemistry (Washington) 1992-09, Vol.64 (17), p.1978-1984
Hauptverfasser: Alvarez-Zepeda, Aurelio, Barman, Bhajendra N, Martire, Daniel E
Format: Artikel
Sprache:eng
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Zusammenfassung:A thermodynamic approach that considers partitioning of solute molecules between the mobile phase and stationary phase and relates the enthalpy and entropy of solute transfer to the solute partial molar excess quantities is described for the evaluation of the relative contributions of the two phases to solute retention in reversed-phase liquid chromatography.
ISSN:0003-2700
1520-6882
DOI:10.1021/ac00041a037