An integron-associated [beta]-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum [beta]-lactamase IBC-1

An integron-associated [beta]-lactamase (IBC-2) from Pseudomonas aeruginosa is a variant of the extended-spectrum [beta]-lactamase IBC-1

An extended-spectrum [beta]-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. blaIBC-2 was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and G...

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Veröffentlicht in:Journal of antimicrobial chemotherapy 2001-11, Vol.48 (5), p.627
Hauptverfasser: Mavroidi, A, Tzelepi, E, Tsakris, A, Miriagou, V, Sofianou, D, Tzouvelekis, L S
Format: Artikel
Sprache:eng
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Zusammenfassung:An extended-spectrum [beta]-lactamase, IBC-2, produced by a clinical strain of Pseudomonas aeruginosa, was characterized. blaIBC-2 was found, as a gene cassette, to be the sole gene within the variable region of a class 1 integron probably located in the chromosome. IBC-2 is a variant of IBC-1 and GES-1, differing by one amino acid from each of these [beta]-lactamases. When expressed in Escherichia coli, IBC-2 was observed to confer resistance to ceftazidime and decreased susceptibility to other oxyimino-[beta]-lactams.
ISSN:0305-7453
1460-2091