Metal‐Free Access to (E/Z)‐α‐Fluorovinyl Phosphorus Compounds from gem‐Difluorostyrenes
A facile and efficient method for the synthesis of (E/Z)‐α‐fluorovinyl phosphorus compounds from gem‐difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1‐fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excel...
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Veröffentlicht in: | European journal of organic chemistry 2019-02, Vol.2019 (5), p.1170-1177 |
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Sprache: | eng |
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Zusammenfassung: | A facile and efficient method for the synthesis of (E/Z)‐α‐fluorovinyl phosphorus compounds from gem‐difluorostyrenes with diphenylphosphine oxide/dialkyl phosphate and DBU at room temperature was developed. A series of 1‐fluorovinyl phosphine oxides/phosphonates were obtained with moderate to excellent yields in these reactions. Additionally, most isomers (E/Z type) of the target compounds could be easily separated and purified by column chromatography.
A facile and efficient method to synthesize (E/Z)‐α‐fluorovinyl phosphorus compounds from gem‐difluorostyrenes and diphenylphosphine oxide/dialkyl phosphate in the presence of DBU at room temperature was developed. This method may provide a practical and concise route for the synthesis of these phosphorus compounds in material chemistry and drug discovery in the future. |
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ISSN: | 1434-193X 1099-0690 |
DOI: | 10.1002/ejoc.201801602 |