Rituximab in combination with CHOP chemotherapy for the treatment of diffuse large B cell lymphoma in Japan: a retrospective analysis of 1,057 cases from Kyushu Lymphoma Study Group

We performed a retrospective analysis of patients with diffuse large B cell lymphoma treated with rituximab plus CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) as a first-line therapy at 22 hospitals of the Kyushu Lymphoma Study Group. During the period 1996–2005, 1,057 patients (ag...

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Veröffentlicht in:	International journal of hematology 2010-03, Vol.91 (2), p.258-266
Hauptverfasser:	Seki, Ritsuko, Ohshima, Koichi, Nagafuji, Koji, Fujisaki, Tomoaki, Uike, Naokuni, Kawano, Fumio, Gondo, Hisashi, Makino, Shigeyoshi, Eto, Tetsuya, Moriuchi, Yukiyoshi, Taguchi, Fumihiro, Kamimura, Tomohiko, Tsuda, Hiroyuki, Ogawa, Ryosuke, Shimoda, Kazuya, Yamashita, Kiyoshi, Suzuki, Keiko, Suzushima, Hitoshi, Tsukazaki, Kunihiro, Higuchi, Masakazu, Utsunomiya, Atae, Iwahashi, Masahiro, Imamura, Yutaka, Tamura, Kazuo, Suzumiya, Junji, Yoshida, Minoru, Abe, Yasunobu, Matsumoto, Tadashi, Okamura, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Combined Modality Therapy Cyclophosphamide - therapeutic use Disease-Free Survival Doxorubicin - therapeutic use Female Hematologic and hematopoietic diseases Hematology Humans Japan - epidemiology Kaplan-Meier Estimate Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - radiotherapy Male Medical sciences Medicine Medicine & Public Health Middle Aged Multivariate Analysis Oncology Original Article Prednisone - therapeutic use Proportional Hazards Models Retrospective Studies Rituximab Survival Analysis Vincristine - therapeutic use
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Zusammenfassung:	We performed a retrospective analysis of patients with diffuse large B cell lymphoma treated with rituximab plus CHOP (cyclophosphamide, adriamycin, vincristine and prednisone) as a first-line therapy at 22 hospitals of the Kyushu Lymphoma Study Group. During the period 1996–2005, 1,057 patients (aged 22–90 years) were analyzed. Of these, 678 were treated with CHOP, and 379 were treated with rituximab plus CHOP (R-CHOP). The complete response rate was 59.9% in the CHOP group and 67.0% in the R-CHOP group ( P
ISSN:	0925-5710 1865-3774
DOI:	10.1007/s12185-009-0475-2