Betaglycan can act as a dual modulator of TGF-(beta) access to signaling receptors: Mapping of ligand binding and GAG attachment sites

Betaglycan can act as a dual modulator of TGF-(beta) access to signaling receptors: Mapping of ligand binding and GAG attachment sites

Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane serine/threonine kinase. Residues of serine 535 and serine 546 in the uromodulin-related region were identified as the glycosaminogl...

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Veröffentlicht in:The Journal of cell biology 1994-02, Vol.124 (4), p.557
Hauptverfasser: Lopez-Casillas, Fernando, Payne, Helen M, Andres, Janet L, Massague, Joan
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Cellular biology
Membranes
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Zusammenfassung:Betaglycan, also known as the TGF-beta type III receptor, is a membrane-anchored proteoglycan that presents TGF-beta to the type II signaling receptor, a transmembrane serine/threonine kinase. Residues of serine 535 and serine 546 in the uromodulin-related region were identified as the glycosaminoglycan attachment sites.
ISSN:0021-9525
1540-8140