Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kineochore funciton

Role of dynein, dynactin, and CLIP-170 interactions in LIS1 kineochore funciton

Mutations in the human LIS1 gene cause type 1 lissencephaly, a severe brain developmental disease involving gross disorganization of cortical neurons. In lower eukaryotes, LIS1 participates in cytoplasmic dynein-mediated nuclear migration.

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Veröffentlicht in:The Journal of cell biology 2002-03, Vol.156 (6), p.959
Hauptverfasser: Chin-Yin, Tai, Dujardin, Denis L, Faulkner, Nicole E, Vallee, Richard B
Format: Artikel
Sprache:eng
Schlagworte:
Brain
Cellular biology
Disease
Genes
Mutation
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Zusammenfassung:Mutations in the human LIS1 gene cause type 1 lissencephaly, a severe brain developmental disease involving gross disorganization of cortical neurons. In lower eukaryotes, LIS1 participates in cytoplasmic dynein-mediated nuclear migration.
ISSN:0021-9525
1540-8140