Correlation of plasma coagulation tests and fibrinogen Clauss with rotational thromboelastometry parameters and prediction of bleeding in dogs

Correlation of plasma fibrinogen concentration (fibrinogen ) with rotational thromboelastometry (ROTEM) parameters has not been investigated in dogs. To determine the correlation between plasma coagulation tests and fibrinogen with ROTEM parameters and to evaluate their ability to predict bleeding in dogs. Ninety-seven dogs with concurrent determination of fibrinogen and fibrin polymerization test (FIBTEM) analysis. Signalment, pretreatment, clinical signs of bleeding, fibrinogen , plasma coagulation test results, hematocrit, platelet count, FIBTEM, extrinsic (EXTEM) and intrinsic (INTEM) activated ROTEM assays were retrieved retrospectively. Correlations between fibrinogen and FIBTEM maximum clot firmness (MCF ) and between prothrombin time (PT) or activated partial thromboplastin time (aPTT) and ROTEM parameters were determined. Dogs were further assigned to groups with or without clinical signs of bleeding. The prognostic significance of significantly different parameters to predict bleeding was evaluated. Fibrinogen showed strong correlation with MCF (r = 0.860, n = 97, P