INFLUENCE OF LYCOPENE ADMINISTRATION ON NEOPTERIN, MYELOPEROXIDASE AND GAMMA GLUTAMYL TRANSFERASE IN DIABETIC RATS

In this study, it was aimed to investigate the influence of lycopene administration on serum Neopterin (NEO), Myeleperoxidase (MPO) and Gamma glutamil tramsferase (GGT) activity in rats with experimentally induced diabetes. Male Wistar-Albino rats aged 7-8 weeks and weighing 250-300 gr were used in the study. Rats were randomly allocated to four groups as control, lycopene, diabetes and diabetes -lycopene with 7 rats in each. 45 mg/kg streptozotocin (STZ) prepared in cold citrate buffer was applied via intraperitoneal route in order to induce experimental diabetes. Lycopene was prepared in corn oil and administered via peroral route through gavage in the dose of 10 mg/kg daily in lycopene and DL groups. Blood samples were taken into serum tubes from the hearts of the rats under general anesthesia at the end of 28 days of test period. Blood samples were centrifuged and serum was obtained. Neopterin, MPO and GGT activities were determined in serum samples. The lowest neopterin level was detected in control group (p