In vitro cytotoxicity studies of surface modified CaS nanoparticles on L929 cell lines using MTT assay

[Display omitted] •In vitro cytotoxicity of TEOA capped CaS nanoparticles were analyzed.•It was done on human L929 fibroblasts cells using MTT assay and direct microscopy.•The cell viability was more than 90% for concentration ranging from 6.25 to 100 µg/mL.•The IC50 value was calculated and was found to be 710 µg/mL. Recently, CaS nanoparticles have attracted great interest because of their use in various biomedical applications. The nanoparticles should be biocompatible for its application in the biomedical field. We synthesized highly luminescent CaS nanoparticles capped with Triethanolamine (TEOA) using wet chemical coprecipitation method and its structural and optical characterization were done. The cytotoxicity analysis was carried out in human fibroblast cell lines using MTT assay, and cell imaging was done using an inverted phase contrast tissue culture microscope. The percentage viability of the samples was compared with control and the IC50 value of the nanoparticles was calculated.