PROTECTIVE EFFECT OF ELLAGIC ACID AGAINST CARBON TETRACHLORIDE (CCL^sub 4^) - INDUCED OXIDATIVE BRAIN INJURY IN RATS

PROTECTIVE EFFECT OF ELLAGIC ACID AGAINST CARBON TETRACHLORIDE (CCL^sub 4^) - INDUCED OXIDATIVE BRAIN INJURY IN RATS

In this study, it was aimed to investigate protective effects of Ellagic acid in rats which have brain damage formed with carbon tetrachloride (CCl4). 28 male Wistar albino rats were separated into 4 groups as Control, CCl4., Ellagic acid and CCl4+ Ellagic acid. From the brain tissue homogenate malo...

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Veröffentlicht in:Fresenius environmental bulletin 2018-05, Vol.27 (5), p.3148
Hauptverfasser: Akkoyun, H Turan, Bengu, Aydin Sukru, Ulucan, Aykut, Bayramoglu-Akkoyun, Mahire, Arihan, Okan
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Antioxidants
Brain
Brain damage
Brain injury
Carbon
Carbon tetrachloride
Catalase
Ellagic acid
Glutathione
Head injuries
Lesions
Malondialdehyde
Peroxidase
Rats
Superoxide dismutase
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Zusammenfassung:In this study, it was aimed to investigate protective effects of Ellagic acid in rats which have brain damage formed with carbon tetrachloride (CCl4). 28 male Wistar albino rats were separated into 4 groups as Control, CCl4., Ellagic acid and CCl4+ Ellagic acid. From the brain tissue homogenate malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), gluthation peroxidase (GSH-Px), catalase (CAT) levels were measured and routine histopathological investigation was performed. An increase in MDA level (p
ISSN:1018-4619
1610-2304