Reevaluation of the Fundamental Dose–Response Relationship

Reevaluation of the Fundamental Dose–Response Relationship

The U-shaped response in toxicological and pharmacological experiments is highly generalized, being independent of phylum, chemical class, and biological endpoint.

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Bibliographische Detailangaben
Veröffentlicht in:Bioscience 1999-09, Vol.49 (9), p.725-732
Hauptverfasser: Calabrese, Edward J., Baldwin, Linda A.
Format: Artikel
Sprache:eng
Schlagworte:
Defense Mechanisms
Disease Incidence
Expectation
Feedback (Response)
Hazardous materials
Pharmacology
Risk Assessment
Toxicology
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Beschreibung
Zusammenfassung:The U-shaped response in toxicological and pharmacological experiments is highly generalized, being independent of phylum, chemical class, and biological endpoint.
ISSN:0006-3568
1525-3244
DOI:10.2307/1313596