Discovery of highly insecticidal synthetic spinosyn mimics – CAMD enabled de novo design simplifying a complex natural product

Discovery of highly insecticidal synthetic spinosyn mimics – CAMD enabled de novo design simplifying a complex natural product

Simplifying complex natural products: Computer modeling‐based design leads to highly insecticidal, chemically simpler synthetic mimics of the spinosyn natural products that are active in the field. © 2018 Society of Chemical Industry CAMD enabled design of synthetic spinosyn mimics. Simplifying comp...

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Veröffentlicht in:Pest management science 2019-02, Vol.75 (2), p.309-313
Hauptverfasser: Sparks, Thomas C, Crouse, Gary D, Demeter, David A, Samaritoni, Geno, McLeod, Casandra L
Format: Artikel
Sprache:eng
Schlagworte:
Biological Products - analysis
Computer Simulation
Drug Design
insecticide discoverymacrolidesynthetic
Insecticides - analysis
Macrolides - analysis
mimics
natural product
Natural products
Organic chemistry
spinosyn
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Zusammenfassung:Simplifying complex natural products: Computer modeling‐based design leads to highly insecticidal, chemically simpler synthetic mimics of the spinosyn natural products that are active in the field. © 2018 Society of Chemical Industry CAMD enabled design of synthetic spinosyn mimics. Simplifying complex natural products: Computer modeling‐based design leads to highly insecticidal, chemically simpler syntheticmimics of the spinosyn natural products that are active in the field.
ISSN:1526-498X
1526-4998
DOI:10.1002/ps.5217