Evaluation of the analgesic and anti-inflammatory activities of methanolic extracts of the leaves of Averrhoa bilimbi leaves

Objectives: This study was aimed to investigate the analgesic and anti-inflammatory activities of crude methanolic extract Averrhoa bilimbi leaves. Materials and Methods: Methanolic extracts of Averrhoa bilimbi leaves with different concentration were tested for analgesic activity in mouse model by acetic acid induced writhing and anti-inflammatory effect was tested by carrageenan induced paw edema model Results: The extract, at 400 mg/kg, showed higher analgesic activity (67.51%) against acetic acid induced pain in mice while the standard reference drug Diclofenac sodium exhibited 64.33% activity at 10 mg/kg dose. The anti-inflammatory effect of the extract was comparable to reference drug Ibuprofen and the effect was sustained for 2-4 hr. Conclusion: Methanolic extractof Averrhoa bilimbi leaves have moderate analgesic and anti-inflammatory properties.