Clinical outcomes and inflammatory response to single‐incision laparoscopic (SIL) colorectal surgery: a single‐blinded randomized controlled pilot study

Aim Single‐incision laparoscopic (SIL) surgery is expanding, but its benefits, efficacy and safety compared with conventional laparoscopic (CL) surgery remain unclear. This pilot study examined clinical outcomes and biochemical markers of inflammation for colorectal resections by SIL and CL in a randomized controlled pilot trial. Method Fifty patients undergoing elective colorectal resection were randomized to either SIL or CL. Primary outcomes were operating time and length of stay (LoS); secondary outcomes included combined length of scars, pain scores, complications, Quality of Life EQ5D‐VAS and the inflammatory markers interleukin‐6 (IL‐6), IL‐8 and C‐reactive protein (CRP) at baseline, 2, 6, 24 and 72 h. Results There was no difference in age, gender, body mass index, indications and site of surgery, American Society of Anesthesiologists grade or incidence of previous surgery between the groups. Except for one conversion from SIL to open surgery, surgery was completed as intended. No difference between SIL and CL was found for operating time [median 130 (72–220) vs 130 (90–317) min, respectively, P = 0.528], LoS [median 4 (3–8) vs 4 (2–19)days, P = 0.888] and time to first flatus [2 (1–4) vs 2 (1–5) days, P = 0.374]. The combined length of scars was significantly shorter for SIL [4 (2–18) vs 7 (5–8) cm, P