The isolation of a plasma-derived γγ’ fibrinogen: Fibronectin mixture that forms a novel polymeric matrix

[Display omitted] •A γγ’FI:FN mixture can be isolated at the same ratio as in human plasma.•The γγ’FI:FN mixture at 20–50 mg/ml does not cryoprecipitate at 4 °C.•A solution of γγ’FI at 15–30 mg/ml cryoprecipitates at 4 °C.•A strong fibrin formed (SEMS = 16 kDyne/cm2) at only 9 mg/ml γγ’FI:FN.•Cross-linked fibronectin aggregates periodically associate with γγ’FI fibrin. Human plasma fibronectin (FN) enhances fibrin polymer strength and is typically present at