Antidiabetes effects - Combination of cowpea juice (Vigna sinensis L.), tomato juice (Solanum lycopersicum L.), and green apple juice (Malus sylvestris Mill.) in white male mice

Aim: This study attempts to know the right combination of juice cowpea, tomatoes, and an green apple to a decrease in blood glucose levels in white male mice-induced alloxan 200 mg/kg BW. Materials and Methods: White male mice are grouped into six treatment groups: Normal control, negative controls (CMC-Na 0.5%), positive control (metformin HCl dose of 20 mg/Kg BW), JC I (1:1:1), JC II (0.5:0.5:0.5), and JC III (0.25:0.25:0.25). All groups except normal control induced alloxan dose of 200 mg/Kg BW on the day 0, and treatment continued from day 1 to day 24. The data obtained were blood glucose level of mice before and after treatment. Blood glucose level data were analyzed using Shapiro-Wilk test and continued by analysis of variance with α = 0.01. Results and Discussion: The results showed that there was a decrease in blood glucose level a combination of cowpea juice, tomato juice, and green apple juice at P < 0.01. Conclusion: Combination of cowpea juice, tomatoes, and green apple more effectively lowers the blood glucose levels on white male mice compare from the use of plants singly.