Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine

The Strategic Advisory Group of Experts (SAGE) on Immunization advises WHO on global policies for vaccines. In April, 2016, SAGE issued recommendations on the use of the first licenced dengue vaccine, CYD-TDV. In November, 2017, a retrospective analysis of clinical trial data, stratifying participan...

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Veröffentlicht in:The Lancet infectious diseases 2019-01, Vol.19 (1), p.e31-e38
Hauptverfasser: Wilder-Smith, Annelies, Hombach, Joachim, Ferguson, Neil, Selgelid, Michael, O'Brien, Kate, Vannice, Kirsten, Barrett, Alan, Ferdinand, Elizabeth, Flasche, Stefan, Guzman, Maria, Novaes, Hillegonde Maria, Ng, Lee-Ching, Smith, Peter G, Tharmaphornpilas, Piyanit, Yoon, In-Kyu, Cravioto, Alejandro, Farrar, Jeremy, Nolan, Terry M
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container_end_page e38
container_issue 1
container_start_page e31
container_title The Lancet infectious diseases
container_volume 19
creator Wilder-Smith, Annelies
Hombach, Joachim
Ferguson, Neil
Selgelid, Michael
O'Brien, Kate
Vannice, Kirsten
Barrett, Alan
Ferdinand, Elizabeth
Flasche, Stefan
Guzman, Maria
Novaes, Hillegonde Maria
Ng, Lee-Ching
Smith, Peter G
Tharmaphornpilas, Piyanit
Yoon, In-Kyu
Cravioto, Alejandro
Farrar, Jeremy
Nolan, Terry M
description The Strategic Advisory Group of Experts (SAGE) on Immunization advises WHO on global policies for vaccines. In April, 2016, SAGE issued recommendations on the use of the first licenced dengue vaccine, CYD-TDV. In November, 2017, a retrospective analysis of clinical trial data, stratifying participants according to their dengue serostatus before the first vaccine dose, showed that although in high seroprevalence settings the vaccine provides overall population benefit, there was an excess risk of severe dengue in seronegative vaccinees. SAGE's working group on dengue vaccines met to discuss the new data and mainly considered two vaccination strategies: vaccination of populations with dengue seroprevalence rates above 80% or screening of individuals before vaccination, and vaccinating only seropositive individuals. We report on the deliberations that informed the recommendation of the pre-vaccination screening strategy, in April, 2018. Important research and implementation questions remain for CYD-TDV, including the development of a highly sensitive and specific rapid diagnostic test to determine serostatus, simplified immunisation schedules, and assessment of the need for booster doses.
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In April, 2016, SAGE issued recommendations on the use of the first licenced dengue vaccine, CYD-TDV. In November, 2017, a retrospective analysis of clinical trial data, stratifying participants according to their dengue serostatus before the first vaccine dose, showed that although in high seroprevalence settings the vaccine provides overall population benefit, there was an excess risk of severe dengue in seronegative vaccinees. SAGE's working group on dengue vaccines met to discuss the new data and mainly considered two vaccination strategies: vaccination of populations with dengue seroprevalence rates above 80% or screening of individuals before vaccination, and vaccinating only seropositive individuals. We report on the deliberations that informed the recommendation of the pre-vaccination screening strategy, in April, 2018. 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subjects Adolescent
Age groups
Child
Child, Preschool
Cost analysis
Dengue fever
Dengue hemorrhagic fever
Dengue Vaccines - adverse effects
Dengue Vaccines - immunology
Dengue Virus - immunology
Diagnostic systems
Disease
Female
Humans
Immunization
Immunization, Secondary
Infections
Infectious diseases
Licenses
Male
Mass Screening
Population
Public health
Schedules
Screening
Seroepidemiologic Studies
Serology
Severe Dengue - prevention & control
Severe Dengue - virology
Treatment Outcome
Vaccination
Vaccines
Vaccines, Attenuated - immunology
Vector-borne diseases
Working groups
World Health Organization
title Deliberations of the Strategic Advisory Group of Experts on Immunization on the use of CYD-TDV dengue vaccine
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