PREVENTION OF INTRAVENTRICULAR HAEMORRHAGE IN PRETERM INFANTS BY PHENOBARBITONE: A Controlled Trial

PREVENTION OF INTRAVENTRICULAR HAEMORRHAGE IN PRETERM INFANTS BY PHENOBARBITONE: A Controlled Trial

Sixty infants with birth-weights less than 1500 g and who were less than 6 h old were randomly assigned to a group given phenobarbitone or a control group. Intravenous phenobarbitone was given in doses sufficient to achieve anticonvulsant serum levels within 12-18 h. Maintenance therapy was continue...

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Veröffentlicht in:The Lancet (British edition) 1981-08, Vol.318 (8240), p.215-217
Hauptverfasser: Donn, StevenM, Roloff, DietrichW, Goldstein, GaryW
Format: Artikel
Sprache:eng
Schlagworte:
Anticonvulsants
Hemorrhage
Infants
Intravenous administration
Newborn babies
Premature babies
Risk analysis
Risk factors
Serum levels
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Zusammenfassung:Sixty infants with birth-weights less than 1500 g and who were less than 6 h old were randomly assigned to a group given phenobarbitone or a control group. Intravenous phenobarbitone was given in doses sufficient to achieve anticonvulsant serum levels within 12-18 h. Maintenance therapy was continued for one week. Periventricular/intraventricular haemorrhage (IVH) occurred in 133% (4/30) of the phenobarbitone group and in 46.7% (14/30) of the control group. The occurrence of risk factors related to IVH was similar in the two groups. Phenobarbitone may reduce the incidence of IVH in small preterm infants.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(81)90470-0