ECOGENETICS OF PARKINSON'S DISEASE: 4-HYDROXYLATION OF DEBRISOQUINE

It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing. Many potentially neurotoxic xenobiotics are detoxified by hepatic cytochrome P450. The function of one such system was studied in...

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Veröffentlicht in:	The Lancet (British edition) 1985-11, Vol.326 (8466), p.1213-1216
Hauptverfasser:	Barbeau, André, Roy, Madeleine, Paris, Suzanne, Cloutier, Thérèse, Plasse, Lorraine, Poirier, Judes
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Basal ganglia Biological and medical sciences Central nervous system diseases Cytochrome P450 Cytochromes P450 Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease control Environmental factors Hydroxylation Medical sciences Movement disorders Neurodegenerative diseases Neurology Neurotoxicity Parkinson's disease Xenobiotics
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Zusammenfassung:	It is postulated that Parkinson's disease is the result of environmental factors acting on genetically susceptible individuals against a background of normal ageing. Many potentially neurotoxic xenobiotics are detoxified by hepatic cytochrome P450. The function of one such system was studied in forty patients with Parkinson's disease and forty normal control subjects. Significantly more parkinsonian than control subjects had partially or totally defective 4-hydroxylation of debrisoquine. Poor metabolisers of debrisoquine tended to have had earlier onset of disease.
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(85)90743-3