EPIDURAL MORPHINE IN TREATMENT OF PAIN

EPIDURAL MORPHINE IN TREATMENT OF PAIN

Epidural injections of 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid spa...

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Veröffentlicht in:The Lancet (British edition) 1979-03, Vol.313 (8115), p.527-529
Hauptverfasser: Behar, M., Olshwang, D., Magora, F., Davidson, J.T.
Format: Artikel
Sprache:eng
Schlagworte:
Chronic pain
Morphine
Pain
Receptors
Spinal cord
Subarachnoid space
Substantia gelatinosa
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Zusammenfassung:Epidural injections of 2 mg morphine were given to 10 patients with severe acute or chronic pain. All cases had considerable amelioration of pain, which commenced within 2-3 min, reached a peak in 10-15 min, and was effective for 6-24 h. It is suggested that the morphine reached the subarachnoid space and produced its effect by direct action on the specific opiate receptors in the substantia gelatinosa of the posterior-horn cells of the spinal cord.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(79)90947-4