GLUCOSE INTOLERANCE DURING DIURETIC THERAPY: Results of Trial by the European Working Party on Hypertension in the Elderly

GLUCOSE INTOLERANCE DURING DIURETIC THERAPY: Results of Trial by the European Working Party on Hypertension in the Elderly

119 elderly, hypertensive patients were followed-up for 1 year and 48 for 2 years in a double-blind, randomised, controlled trial in which they received either placebo or 25-50 mg hydrochlorothiazide and 50-100 mg of triamterene daily. Half of the active treatment group also received 250 mg to 2 g m...

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Veröffentlicht in:The Lancet (British edition) 1978-04, Vol.311 (8066), p.681-683
Hauptverfasser: Amery, A., Bulpitt, C., Schaepdryver, A.De, Fagard, R., Hellemans, J., Mutsers, A., Berthaux, P., Deruyttere, M., Dollery, C., Forette, F., Lund-Johansen, P., Tuomilehto, J.
Format: Artikel
Sprache:eng
Schlagworte:
Blood
Diuretics
Geriatrics
Glucose
Glucose tolerance
Hydrochlorothiazide
Hyperglycemia
Intolerance
Methyldopa
Older people
Patients
Potassium
Sugar
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Zusammenfassung:119 elderly, hypertensive patients were followed-up for 1 year and 48 for 2 years in a double-blind, randomised, controlled trial in which they received either placebo or 25-50 mg hydrochlorothiazide and 50-100 mg of triamterene daily. Half of the active treatment group also received 250 mg to 2 g methyldopa daily. After 2 years the active treatment group had an average increase in fasting blood-sugar of 9·6 mg/dl compared with an average fall of 3·1 mg in the placebo group (P
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(78)90797-3