Synthesis and anti-tuberculosis activity of trisindolines

Synthesis and anti-tuberculosis activity of trisindolines

The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b)...

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Bibliographische Detailangaben
Hauptverfasser: Annuur, Rose Malina, Titisari, Dyah Ayu, Dinarlita, Rahma Rahayu, Fadlan, Arif, Ersam, Taslim, Nuryastuti, Titik, Santoso, Mardi
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Synthesis
Tuberculosis
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Beschreibung
Zusammenfassung:The synthesis and antitubercular activity of trisindoline (2) and benzylated trisindolines (3a-b) are reported herein. Trisindoline (2) was synthesized from isatin (1) in 97% yield, in addition benzylated trisindolines (3a-b) from 5-bromo-1-(4-nitrobenzyl)isatin (5a) and 1-benzyl-5-bromoisatin (5b) in 83% and 80% yields, respectively. Antitubercular assay showed that trisindoline (3a) has a better activity to inhibit Micobacterium tuberculosis H37Rv.
ISSN:0094-243X
1551-7616
DOI:10.1063/1.5082493