MEROZOITE VACCINATION OF DOUROUCOULI MONKEYS AGAINST FALCIPARUM MALARIA

MEROZOITE VACCINATION OF DOUROUCOULI MONKEYS AGAINST FALCIPARUM MALARIA

Erythrocytic merozoites of Plasmodium falciparum (Gambia) were isolated from cultures of schizont-infected human red cells on CF 11 cellulose columns. Douroucouli monkeys vaccinated with such preparations stored in liquid nitrogen and then emulsified in Freund's complete adjuvant (F.C.A.), were...

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Veröffentlicht in:The Lancet (British edition) 1977-06, Vol.309 (8026), p.1335-1338
Hauptverfasser: Mitchell, G.H., Butcher, G.A., Richards, W.H.G., Cohen, S.
Format: Artikel
Sprache:eng
Schlagworte:
Cellulose
Erythrocytes
Immunity
Liquid nitrogen
Malaria
Merozoites
Monkeys
Plasmodium falciparum
Vaccination
Vector-borne diseases
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Zusammenfassung:Erythrocytic merozoites of Plasmodium falciparum (Gambia) were isolated from cultures of schizont-infected human red cells on CF 11 cellulose columns. Douroucouli monkeys vaccinated with such preparations stored in liquid nitrogen and then emulsified in Freund's complete adjuvant (F.C.A.), were resistant to successive challenges with West African (Lagos) and East African (Uganda Palo-Alto) strains of P. falciparum. The induced immunity is specific since vaccination with P. knowlesi merozoites in F.C.A. does not modify the course of P. falciparum infections in douroucouli monkeys.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(77)92551-X