A TESTOSTERONE-SECRETING TUMOUR OF THE ADRENAL PRODUCING VIRILISATION IN A FEMALE INFANT

A TESTOSTERONE-SECRETING TUMOUR OF THE ADRENAL PRODUCING VIRILISATION IN A FEMALE INFANT

A 20-month-old girl presented with signs of virilisation. Her endocrine function was essentially normal except for the peripheral testosterone levels which were equivalent to those found in early puberty in males. Selective venous sampling revealed that testosterone concentration was highest in the...

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Veröffentlicht in:The Lancet (British edition) 1973-09, Vol.302 (7830), p.643-644
Hauptverfasser: Burr, I.M., Graham, T., Sullivan, J., Hartman, W.H., O'Neill, J.
Format: Artikel
Sprache:eng
Schlagworte:
Adrenal glands
Puberty
Testosterone
Tumors
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Zusammenfassung:A 20-month-old girl presented with signs of virilisation. Her endocrine function was essentially normal except for the peripheral testosterone levels which were equivalent to those found in early puberty in males. Selective venous sampling revealed that testosterone concentration was highest in the left renal vein. Subsequently a tumour was removed from the left adrenal. Histologically this tumour contained areas with features similar to the primitive sex cord. Postoperative follow-up over 15 months has been uneventful.
ISSN:0140-6736
1474-547X
DOI:10.1016/S0140-6736(73)92480-X