$Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies$

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies

Summary We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1.14–1.28, p

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Bibliographische Detailangaben
Veröffentlicht in:	Osteoporosis international 2019-01, Vol.30 (1), p.103-114
Hauptverfasser:	Poly, T.N., Islam, M.M., Yang, H.-C., Wu, C.C., Li, Y.-C.(.J.).
Format:	Artikel
Sprache:	eng
Schlagworte:	Dose-Response Relationship, Drug Drug Administration Schedule Endocrinology Fractures Gastroesophageal reflux Health risk assessment Hip Hip Fractures - chemically induced Humans Medicine Medicine & Public Health Meta-analysis Observational studies Observational Studies as Topic Original Article Orthopedics Osteoporosis Osteoporotic Fractures - chemically induced Patients Proton pump inhibitors Proton Pump Inhibitors - administration & dosage Proton Pump Inhibitors - adverse effects Rheumatology Risk Assessment - methods
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Beschreibung
Zusammenfassung:	Summary We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1.14–1.28, p
ISSN:	0937-941X 1433-2965
DOI:	10.1007/s00198-018-4788-y