Passive Smoking, Cytochrome P450 Gene Polymorphisms and Dysmenorrhea

Purpose This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYPlAlMspI and CYPlAlHincII. Methods This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding fema...

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Veröffentlicht in:European journal of epidemiology 2008-07, Vol.23 (7), p.475-481
Hauptverfasser: Lei, Lou, Ye, Linan, Liu, Hong, Chen, Changzhong, Fang, Zhian, Wang, Lihua, Hu, Yonghua, Chen, Dafang
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Sprache:eng
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Zusammenfassung:Purpose This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYPlAlMspI and CYPlAlHincII. Methods This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress. Results In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0–3.3) in CYPlAlMspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1–7.7) in CYPlAlHincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2- 2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0–2.1) with C/ C6235 genotype, compared to non- passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYPlA1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0–2.1), and Hindi He/ Ile462 (OR = 1.6, 95% CI = 1.2–2.1), respectively. Conclusion CYPlA1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.
ISSN:0393-2990
1573-7284
DOI:10.1007/s10654-008-9250-6